Peer Reviewed

Cortassa S, Aon MA, Winslow RL, O'Rourke B,(9/2004) A mitochondrial oscillator dependent on reactive oxygen species. Biophys J, 87: 2060-73

Wells L, Kreppel LK, Comer FI, Wadzinski BE, Hart GW,(9/2004) O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits. J Biol Chem, 279: 38466-70

Buscemi N, Doherty-Kirby A, Sussman MA, Lajoie G, Van Eyk JE,(9/2003) Proteomic analysis of Rac1 transgenic mice displaying dilated cardiomyopathy reveals an increase in creatine kinase M-chain protein abundance. Mol Cell Biochem, 251: 145-51

Colantonio DA, Van Eyk JE, Przyklenk K,(8/2004) Stunned peri-infarct canine myocardium is characterized by degradation of troponin T, not troponin I. Cardiovasc Res, 63: 217-25

Kristiansen TZ, Bunkenborg J, Gronborg M, Molina H, Thuluvath PJ, Argani P, Goggins MG, Maitra A, Pandey A,(7/2004) A proteomic analysis of human bile. Mol Cell Proteomics, 3: 715-28

Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX,(7/2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A, 101: 10804-9

Von Seggern CE, Cotter RJ,(7/2004) Study of peptide-sugar non-covalent complexes by infrared atmospheric pressure matrix-assisted laser desorption/ionization. J Mass Spectrom, 39: 736-42

Zachara NE, Hart GW,(7/2004) O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress. Biochim Biophys Acta, 1673: 13-28

Zachara NE, O'Donnell N, Cheung WD, Mercer JJ, Marth JD, Hart GW,(7/2004) Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells. J Biol Chem, 279: 30133-42

Gao Y, Miyazaki J, Hart GW,(7/2003) The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells. Arch Biochem Biophys, 415: 155-63

Iyer SP, Hart GW,(7/2003) Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity. J Biol Chem, 278: 24608-16

McDonald TG, Van Eyk JE,(7/2003) Mitochondrial proteomics. Undercover in the lipid bilayer. Basic Res Cardiol, 98: 219-27

Von Seggern CE, Moyer SC, Cotter RJ,(7/2003) Liquid infrared atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry of sialylated carbohydrates. Anal Chem, 75: 3212-8

Wells L, Hart GW,(7/2003) O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar. FEBS Lett, 546: 154-8

Labugger R, Simpson JA, Quick M, Brown HA, Collier CE, Neverova I, Van Eyk JE,(6/2003) Strategy for analysis of cardiac troponins in biological samples with a combination of affinity chromatography and mass spectrometry. Clin Chem, 49: 873-9

Moyer SC, VonSeggern CE, Cotter RJ,(6/2003) Fragmentation of cationized phosphotyrosine containing peptides by atmospheric pressure MALDI/Ion trap mass spectrometry. J Am Soc Mass Spectrom, 14: 581-92

Stanley BA, Neverova I, Brown HA, Van Eyk JE,(6/2003) Optimizing protein solubility for two-dimensional gel electrophoresis analysis of human myocardium. Proteomics, 3: 815-20

Zachara NE, Hart GW,(5/2004) O-GlcNAc modification: a nutritional sensor that modulates proteasome function. Trends Cell Biol, 14: 218-21

McFawn PK, Shen L, Vincent SG, Mak A, Van Eyk JE, Fisher JT,(5/2003) Calcium-independent contraction and sensitization of airway smooth muscle by p21-activated protein kinase. Am J Physiol Lung Cell Mol Physiol, 284: L863-70

Cotter RJ, Gardner BD, Iltchenko S, English RD,(4/2004) Tandem time-of-flight mass spectrometry with a curved field reflectron. Anal Chem, 76: 1976-81

Granger CB, Van Eyk JE, Mockrin SC, Anderson NL, ,(4/2004) National Heart, Lung, And Blood Institute Clinical Proteomics Working Group report. Circulation, 109: 1697-703

Ibarrola N, Molina H, Iwahori A, Pandey A,(4/2004) A novel proteomic approach for specific identification of tyrosine kinase substrates using [13C]tyrosine. J Biol Chem, 279: 15805-13

Thompson PR, Wang D, Wang L, Fulco M, Pediconi N, Zhang D, An W, Ge Q, Roeder RG, Wong J, Levrero M, Sartorelli V, Cotter RJ, Cole PA,(4/2004) Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol, 11: 308-15

Cortassa S, Aon MA, Marbán E, Winslow RL, O'Rourke B,(4/2003) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J, 84: 2734-55

Akimoto Y, Comer FI, Cole RN, Kudo A, Kawakami H, Hirano H, Hart GW,(3/2003) Localization of the O-GlcNAc transferase and O-GlcNAc-modified proteins in rat cerebellar cortex. Brain Res, 966: 194-205

English RD, Cotter RJ,(3/2003) A miniaturized matrix-assisted laser desorption/ionization time of flight mass spectrometer with mass-correlated acceleration focusing. J Mass Spectrom, 38: 296-304

Iyer SP, Hart GW,(3/2003) Dynamic nuclear and cytoplasmic glycosylation: enzymes of O-GlcNAc cycling. Biochemistry, 42: 2493-9

Wells L, Whelan SA, Hart GW,(3/2003) O-GlcNAc: a regulatory post-translational modification. Biochem Biophys Res Commun, 302: 435-41

Grĝnborg M, Bunkenborg J, Kristiansen TZ, Jensen ON, Yeo CJ, Hruban RH, Maitra A, Goggins MG, Pandey A,(2004) Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res, 3: 1042-55

Stanley BA, Gundry RL, Cotter RJ, Van Eyk JE,(2004) Heart disease, clinical proteomics and mass spectrometry. Dis Markers, 20: 167-78

Wang D, Kalb SR, Cotter RJ,(2004) Improved procedures for N-terminal sulfonation of peptides for matrix-assisted laser desorption/ionization post-source decay peptide sequencing. Rapid Commun Mass Spectrom, 18: 96-102

Zachara NE, Cheung WD, Hart GW,(2004) Nucleocytoplasmic glycosylation, O-GlcNAc: identification and site mapping. Methods Mol Biol, 284: 175-94

Dos Remedios CG, Liew CC, Allen PD, Winslow RL, Van Eyk JE, Dunn MJ,(2003) Genomics, proteomics and bioinformatics of human heart failure. J Muscle Res Cell Motil, 24: 251-60

Hart GW,(2003) Structural and functional diversity of glycoconjugates: a formidable challenge to the glycoanalyst. Methods Mol Biol, 213: 3-24

Kamemura K, Hart GW,(2003) Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: a new paradigm for metabolic control of signal transduction and transcription. Prog Nucleic Acid Res Mol Biol, 73: 107-36

Wells L, Vosseller K, Cole RN, Cronshaw JM, Matunis MJ, Hart GW.(2002) Mapping Sites of O-GlcNAc Modification Using Affinity Tags for Serine and Threonine Post-translational Modifications Mol Cell Proteomics, 10: 791-804

Chou TY, Hart GW,(2001) O-linked N-acetylglucosamine and cancer: messages from the glycosylation of c-Myc. Adv Exp Med Biol, 491: 413-8

Hart GW, Lowe JB, Sathyamoorthy N,(2/2004) Glycobiology and cancer: meeting summary and future diections. Cancer Biol Ther, 3: 233-7

Hermjakob H, Montecchi-Palazzi L, Bader G, Wojcik J, Salwinski L, Ceol A, Moore S, Orchard S, Sarkans U, von Mering C, Roechert B, Poux S, Jung E, Mersch H, Kersey P, Lappe M, Li Y, Zeng R, Rana D, Nikolski M, Husi H, Brun C, Shanker(2/2004) The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol, 22: 177-83

O'Donnell N, Zachara NE, Hart GW, Marth JD,(2/2004) Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol, 24: 1680-90

Simpson JA, Van Eyk J, Iscoe S,(2/2004) Respiratory muscle injury, fatigue and serum skeletal troponin I in rat. J Physiol, 554: 891-903

Van Eyk JE,(2/2004) Lessons from old and new kinases. Circ Res, 94: 135-7

Iyer SP, Akimoto Y, Hart GW,(2/2003) Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. J Biol Chem, 278: 5399-409

Kalume DE, Molina H, Pandey A,(2/2003) Tackling the phosphoproteome: tools and strategies. Curr Opin Chem Biol, 7: 64-9

Wells L, Vosseller K, Hart GW,(2/2003) A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance. Cell Mol Life Sci, 60: 222-8

Elliott ST, Crider DG, Garham CP, Boheler KR, Van Eyk JE,(12/2004) Two-dimensional gel electrophoresis database of murine R1 embryonic stem cells. Proteomics, 4: 3813-32

Elliott ST, Crider DG, Garham CP, Boheler KR, Van Eyk JE,(12/2004) Two-dimensional gel electrophoresis database of murine R1 embryonic stem cells. Proteomics, 4: 4032

Gardner LB, Li F, Yang X, Dang CV,(12/2003) Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1a. Mol Cell Biol, 23: 9032-45

Li MX, Wang X, Lindhout DA, Buscemi N, Van Eyk JE, Sykes BD,(12/2003) Phosphorylation and mutation of human cardiac troponin I deferentially destabilize the interaction of the functional regions of troponin I with troponin C. Biochemistry, 42: 14460-8

Vosseller K, Sakabe K, Wells L, Hart GW,(12/2002) Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification. Curr Opin Chem Biol, 6: 851-7

Murphy AM,(11/2004) Another new kinase targets troponin I. Circ Res, 95: 1043-5

Foster DB, Noguchi T, VanBuren P, Murphy AM, Van Eyk JE,(11/2003) C-terminal truncation of cardiac troponin I causes divergent effects on ATPase and force: implications for the pathophysiology of myocardial stunning. Circ Res, 93: 917-24

Ibarrola N, Kalume DE, Gronborg M, Iwahori A, Pandey A,(11/2003) A proteomic approach for quantitation of phosphorylation using stable isotope labeling in cell culture. Anal Chem, 75: 6043-9

Whelan SA, Hart GW,(11/2003) Proteomic approaches to analyze the dynamic relationships between nucleocytoplasmic protein glycosylation and phosphorylation. Circ Res, 93: 1047-58

Xu W, Liu Y, Wang S, McDonald T, Van Eyk JE, Sidor A, O'Rourke B,(11/2002) Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science, 298: 1029-33

Von Seggern CE, Gardner BD, Cotter RJ,(10/2004) Infrared atmospheric pressure MALDI ion trap mass spectrometry of frozen samples using a Peltier-cooled sample stage. Anal Chem, 76: 5887-93

Slawson C, Hart GW,(10/2003) Dynamic interplay between O-GlcNAc and O-phosphate: the sweet side of protein regulation. Curr Opin Struct Biol, 13: 631-6

Von Seggern CE, Cotter RJ,(10/2003) Fragmentation studies of noncovalent sugar-sugar complexes by infrared atmospheric pressure MALDI. J Am Soc Mass Spectrom, 14: 1158-65

Wells L, Vosseller K, Cole RN, Cronshaw JM, Matunis MJ, Hart GW,(10/2002) Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications. Mol Cell Proteomics, 1: 791-804

Gewinner C, Hart G, Zachara N, Cole R, Beisenherz-Huss C, Groner B,(1/2004) The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5. J Biol Chem, 279: 3563-72

Peri S, Navarro JD, Kristiansen TZ, Amanchy R, Surendranath V, Muthusamy B, Gandhi TK, Chandrika KN, Deshpande N, Suresh S, Rashmi BP, Shanker K, Padma N, Niranjan V, Harsha HC, Talreja N, Vrushabendra BM, Ramya MA, Yatish AJ, Joy M, S(1/2004) Human protein reference database as a discovery resource for proteomics. Nucleic Acids Res, 32 Database issue: D497-501

Von Seggern CE, Zarek PE, Cotter RJ, (2003) Fragmentation of Sialylated Carbohydrates Using Infrared Atmospheric Pressure MALDI Ion Trap Mass Spectrometry from Cation-Doped Liquid Matrixes, Anal. Chem. 75: 6523?6530.

Zachara NE, Cheung WD, Hart GW (2004). O-GlcNAc, an essential post-translational modification of nucleocytoplasmic proteins. Current Organic Chemistry, 8, 369-383.

Lakshmanan T, Hart GW (2004) O-GlcNAc: a multifaceted post-translational modification. Bio Tech Intl. 16(3): 6-9.