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Biological Aim 1
Biological Aim 2
Biological Aim 3
Biological Aim 4
Biological Aim 5
Biological Aim 6
Technical Aim 1
Technical Aim 2
Technical Aim 3
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Research Projects

The research goals of the center are divided between the Biological Challenges which then drive the creation of Technical inovations. Please select one of the Biological Challenges or Technical Inovations from the menu below to see a complete description of that Challenge or Inovation.

Biological Challenge 1: Hypoxia-inducible factor HIF1 TICC: Technical Implementation and Coordination Core Technical Innovation 1: Development of novel proteomic methods to study glycosylation and phosphorylation and dynamic changes to the proteome
Biological Challenege 2: Myosin Light Chain Kinase in Lung Hypoxia Technical Innovation 1: Development of novel proteomic methods to study glycosylation and phosphorylation and dynamic changes to the proteome
Technical Innovation 1 Aim 4: Development of novel proteomic methods to study glycosylation and phosphorylation and dynamic changes to the proteome
Biological Challenge 3: Hematopoesis
Technical Innovation 1 Aim1: Improved Protein Quantification
Biological Challenge 4: Cardioprotection
Technical Innovation 2: Novel Instrumentation and Methods
Biological Challenge 5: Myocardial Stunning
Biological Challenge 6: Serum markers of Clinical Ischemia Technical Innovation 3: Informatics and Modeling

Biological Aim 1

Post-translational modifications of HIF-1alpha and their functional significance

Biological Aim 2

Lung endothelial cytoskeletal responses to ischemia

Biological Aim 3

Proteomic consequences of hypoxia on cell proliferation

Biological Aim 4

Mechanisms of ischemic preconditioning and cardioprotection

Biological Aim 5

Functional importance of proteomic changes in myocardial stunning

Biological Aim 6

Identification and detection of novel serum biomarkers of myocardial ischemia in humans

Technical Aim 1

Improved Methods for Tracking Dynamic Protein or Post-translational modification changes in disease.

Technical Aim 2

Develop Improved Instrumentation & Methods Taking Advantage of Novel Capabilities

Technical Aim 3

Computational Analysis and Dynamic Modeling of Subproteomes

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