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The mission of the Johns Hopkins NHLBI Proteomics Center is to apply state-of-the-art methods and to develop new approaches and techniques to investigate the proteomics of adaptation to ischemia and hypoxia, a biological process of general relevance to heart, lung and blood diseases. The Center builds on resources provided by Hopkins' Institute for Cell Engineering, a shared instrumentation grant from the National Institutes of Health, and will fund additional staff and faculty to support more than a dozen technology and biology projects.